Piperazine PIP Market Report 2024 (Global Edition)

Global Piperazine PIP Market Report 2024 Market Size Split by Grade (Food Grade, Pharmaceutical Grade, Industrial Grade), by Type (Piperazine Anhydrous, 68 Piperazine, Others), by Application (Adhesiv...

Piperazine PIP Market Report Description

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Competitive Landscape of the Piperazine PIP Market

BASF SE

BASF SE is a German-based company engaged in the manufacturing of chemicals. The portfolio of the company comprises six segments: chemicals, materials, industrial solutions, surface technologies, nutrition & care, agricultural solutions, and others. The BASF Group comprises subsidiaries and joint ventures in more than 80 countries and has companies in around 90 countries across the globe. It operates six Verbund sites and 241 additional production sites worldwide.

Nouryon Chemicals Holding B.V.

Nouryon Chemicals Holding B.V. is one of the significant company manufacturing specialty chemicals. The company manufactures and offers different products such as personal care, cleaning goods, paints and coatings, agriculture and food, pharmaceuticals, and building products. The company operates in more than 80 countries worldwide with 11 innovation and application centers worldwide. The company has its two operating business segments namely performance formulations and technology solutions. The company has a total of about 59 manufacturing sites across the globe. Nouryon Chemicals Holding B.V. markets and sells its products under several different brand names such as Dissolvine, Expancel, Trigonox, LevaSil, Butanox, Thioplast, Amphomer, eka, Kromasil, Bermocoll, Solvitar, Berol, Ferrazone, Witbreak, Perkadox, and Akucell. The company's end-markets include agriculture & food, paints & coatings, home & personal care, polymer specialties, natural resources, and renewable fibers.

Recent Developments:

September 2022

Nouryon acquired ADOB Fertilizers

Nouryon entered into a definitive agreement and acquired ADOB Fertilizers, a leading supplier of chelated micronutrients, foliars and other specialty fertilizers. This acquisition enabled Nouryon to expand its product portfolio and broaden its offerings for customers in the crop nutrition market.

Top Companies Market Share in Piperazine PIP Industry: (In no particular order of Rank)

• Dow Chemicals
• BASF
• Nouryon Inc.
• Diamines And Chemicals Limited (DACL)
• Delamine
• Others
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Regional analysis of the Piperazine PIP Revenue Market

North America held the largest market share of 44.28% in 2022 and is estimated to grow with a CAGR of 4.98% during the forecast period. North America has a well-established pharmaceutical industry, which has applications for piperazine. According to EFPIA, in 2022 North America accounted for 52.3% of world pharmaceutical sales. The United States is the worldwide leader in per capita prescription drug spending, representing the major percentage of the worldwide market. Many global pharmaceutical companies also have a presence in the U.S. The major pharmaceutical players in North America include Johnson & Johnson, Eli Lilly and Co, AbbVie Inc, Merck & Co Inc, Amgen Inc, Pfizer Inc, Bristol-Myers Squibb Co, Gilead Sciences Inc, Vertex Pharmaceuticals Inc, Regeneron Pharmaceuticals Inc, and others. These market players hold significant market shares of the North American pharmaceutical market. Further, the research and development infrastructure in North America is also well-developed and investments in drug discoveries are also increasing rapidly. Piperazine plays a vital role in this pharmaceutical industry. Piperazine is used in the development of drugs for various diseases and infections. 

Piperazine, as such or as salts, is mainly used as an intermediate in the chemical industry including the production of pharmaceuticals. Piperazine, as such or as salts, is used also for human and veterinary medicinal drugs, as a formulation in gas-washing (scrubbers), and as a catalyst in urethane production. It belongs to the family of medicines called anthelmintics. Anthelmintics are used in the treatment of worm infections. Piperazine is used to treat common roundworms (ascariasis) and pinworms (enterobiasis; oxyuriasis). Piperazine works by paralyzing the worms. They are then passed in the stool. So, overall, the growing pharmaceutical industry in North America is accelerating the growth of the piperazine market.

The current report Scope analyzes Piperazine PIP Market on 5 major region Split (In case you wish to acquire a specific region edition (more granular data) or any country Edition data then please write us on info@cognitivemarketresearch.com

• North America (United States, Canada, Mexico)
• Europe (United Kingdom, France, Germany, Italy, Russia, Spain, Sweden, Denmark, Netherlands, Switzerland, Belgium)
• Asia-Pacific (China, Japan, Korea, India, Australia, Philippines, Singapore, Malaysia, Thailand, Indonesia, Rest of APAC)
• South America (Brazil, Argentina, Colombia, Peru, Chile, Rest of South America)
• Middle East and Africa (Saudi Arabia, Turkey, Nigeria, UAE, Egypt, South Africa, GCC Countries, Rest of MEA)

The above graph is for illustrative purposes only.

North America Piperazine PIP Market

North America Piperazine PIP market Analysis

North America Piperazine PIP market size was $239.04 Million in 2024 and it is forecasted to reach $321.24 Million by 2030.

North America held the largest market share of 44.28% in 2022 and is estimated to grow with a CAGR of 4.98% during the forecast period. North America has a well-established pharmaceutical industry, which has applications for piperazine. According to EFPIA, in 2022 North America accounted for 52.3% of world pharmaceutical sales. The United States is the worldwide leader in per capita prescription drug spending, representing the major percentage of the worldwide market. Many global pharmaceutical companies also have a presence in the U.S. The major pharmaceutical players in North America include Johnson & Johnson, Eli Lilly and Co, AbbVie Inc, Merck & Co Inc, Amgen Inc, Pfizer Inc, Bristol-Myers Squibb Co, Gilead Sciences Inc, Vertex Pharmaceuticals Inc, Regeneron Pharmaceuticals Inc, and others. These market players hold significant market shares of the North American pharmaceutical market. Further, the research and development infrastructure in North America is also well-developed and investments in drug discoveries are also increasing rapidly. Piperazine plays a vital role in this pharmaceutical industry. Piperazine is used in the development of drugs for various diseases and infections. 

Piperazine, as such or as salts, is mainly used as an intermediate in the chemical industry including the production of pharmaceuticals. Piperazine, as such or as salts, is used also for human and veterinary medicinal drugs, as a formulation in gas-washing (scrubbers), and as a catalyst in urethane production. It belongs to the family of medicines called anthelmintics. Anthelmintics are used in the treatment of worm infections. Piperazine is used to treat common roundworms (ascariasis) and pinworms (enterobiasis; oxyuriasis). Piperazine works by paralyzing the worms. They are then passed in the stool. So, overall, the growing pharmaceutical industry in North America is accelerating the growth of the piperazine market.

Europe Piperazine PIP Market

Europe Piperazine PIP market analysis

Europe Piperazine PIP market size was $140.84 Million in 2024 and it is forecasted to reach $194.27 Million by 2030.

Europe held a significant market share of 25.87% in 2022 for the piperazine market and is estimated to grow with 5.43% CAGR during the forecast period. Piperazine is a chemical compound that can be used for various purposes, including as an ingredient in certain medications, as a precursor in the synthesis of organic compounds, and in the production of some industrial chemicals. In Europe region due to the stable demand for agrochemicals, and the growing pharmaceutical industry are the major factors contributing to the growth of the piperazine market. For instance, between 2011 and 2020 pesticide sales in the EU were almost stable, around 350,000 tonnes per year, in which piperazine can be used as an ingredient owing to its various properties. Further, the pharmaceutical industry in Europe also consists of a major market share of the pharmaceutical industry. Piperazine functions primarily as an intermediate in the production of multiple commodities including pharmaceutical solutions, dyes, and rubber chemicals. In addition, it also has applications in the discovery and development of potent drugs.

Furthermore, piperazine is also gaining popularity in the cosmetic industry. New regulations passed in European countries for the use of piperazine in cosmetic products. For instance, Piperazine and Piperazine (nano) are allowed for use as UV filters up to a maximum concentration of 10% as of July 28, 2023. When they are used in combination, the sum shall not exceed 10%. Furthermore, the law provides additional requirements for Piperazine in nano form. So, the growing use of piperazine in pharmaceutical, chemical, and cosmetic industries are accelerating the market growth in Europe.

Asia Pacific Piperazine PIP Market

Asia Pacific Piperazine PIP market Analysis

Asia Pacific Piperazine PIP market size was $116.07 Million in 2024 and it is forecasted to reach $165.50 Million by 2030.

APAC accounted for the market share of 21.08% in 2022 and is estimated to grow with the CAGR of 6.02% during the forecast period. The growth of the piperazine market in this region is attributed to the growing agrochemical sector, pharmaceuticals and chemical industry expansion, and growth of the pet care industry. Some of the major economies of the APAC are agriculture-based, which require agrochemicals to increase the yield from farms, and to prevent insects and pests. For instance, the following graph represents the Capacity volume of the agrochemical industry across India from FY 2017 to FY 2022

South America Piperazine PIP Market

South America Piperazine PIP market Analysis

South America Piperazine PIP market size was $26.69 Million in 2024 and it is forecasted to reach $35.42 Million by 2030.

Latin America is experiencing growth in the food & beverage, oil and gas, personal care, and cosmetics industries. The growth of these industries is attributed to the growing R&D investments, the development of innovative products, and awareness about the beneficial properties of piperazine as ingredients in various products related to these industries. As the popularity of different cosmetic products is growing in Latin America, spending on these products has been heightened in recent years. For instance, according to reports, the average spending on cosmetics by women in 2018 in Brazil, Chile, Mexico, Peru, and Colombia is USD 936, 646, 602, 541, and 443 respectively. The piperazine and its derivative are used in different beauty and cosmetic products. Piperazine also known as Bis diethylamino hydroxy benzoyl peroxide is used as an ingredient in cosmetic products. Piperazine is used as a UV filter for the protection of skin or hair from harmful UV radiation. The UV filter in sunscreen and other cosmetics with UV protection, minimizes the undesired effects of UV radiation on the skin. Hence, the growing food & beverage, oil and gas, personal care, and cosmetics industries in Latin America is accelerating the growth of the piperazine market.

Middle East and Africa Piperazine PIP Market

Middle East and Africa Piperazine PIP market Analysis

Middle East and Africa Piperazine PIP market size was $20.38 Million in 2024 and it is forecasted to reach $26.63 Million by 2030. 

Middle East and Africa region accounted for the market share of 3.81% in 2022 and is estimated to reach 3.58% in 2030. The growth of the piperazine market in this region is attributed to the huge textile industry and growing food processing industry. The Middle East Textiles had its nodes of Eurasian textile production and trade long before the Islamic period. In the Islamic world, a wide variety of Flex other types of bast fibers including hemp was produced. Both cotton and linen textiles were popularly used throughout the region. These textiles had a complete gamut of heavy cotton canvas produced for sailing ships and extremely fine Muslins. Further, Kenya is one of the leading markets for the African textile industry. In the textile industry, Piperazine is used for the development of fire self-extinguishing cotton fabric, and other types of fabrics. In addition, piperazine-modified silicone oil and emulsion, its side chain contains secondary amine and tertiary amine groups, this kind of special structure to make it used for cotton, linen, wool, and blended fabric, can achieve inhibition yellowing, and the best soft effect. It is a generation of new and excellent fabric finishing agents. So, in the MEA region, growing textile and food processing industries are driving the demand for piperazine.

Piperazine PIP Market Analysis

Piperazine - PIP Market Analysis by Grade

Food Grade

In 2018, the Food Grade Piperazine - PIP revenue (USD Million) was USD 22.61 Million and it expected to reach at USD 29.52 Million in 2030. Food-grade piperazine is a chemical reagent used to inhibit the enzymes in the food industry. Piperazine is used as an indirect food additive in the food and beverage industry. The presence of major manufacturers of piperazine focuses on the expansion of piperazine as an indirect food additive for the growth of the market.
 
Piperazine is an organic compound, which consists of a six-membered ring containing two nitrogen atoms. The piperazine is used as an anthelmintic agent for the treatment of roundworms, and pinworms. Pharmaceutical-grade piperazine is used for the treatment of partial intestinal obstruction caused by Ascaris worms. This condition is common among children. Piperazine hydrate, and piperazine citrate are the main anthelmintic piperazines. Piperazine produces a neuromuscular block which leads to muscle paralysis of the worms, which are consequently dislodged and expelled in faeces. 

It is used as an enzyme inhibitor in the preparation of samples for analysis and process optimization. Piperazine binds to the surface membrane of cells and inhibits the activity of enzymes that are located on this membrane. Piperazine is a pharmacological agent used as an anthelminthic drug for the treatment of metabolic disorders. Major manufacturer such as Thermo Fischer Scientific, and Nouryon, offers piperazine anhydrous, piperazine 68% for synthesis of pharmaceutical drugs such as floxacin, quinolones (antibiotics), phenothiazines

Industrial Grade 

Industrial-grade piperazine is used for the manufacturing of plastics, pesticides, resins, brake fluid, and other industrial materials. Piperazine is also used as the fluid for H2S, and CO2 scrubbing in addition to methyl diethanolamine. Alliance Chemicals, TCI Chemicals uses piperazine anhydrous, for use in industrial applications.

The above Chart is for representative purposes and does not depict actual sale statistics. Access/Request the quantitative data to understand the trends and dominating segment of Piperazine PIP Industry. Request a Free Sample PDF!

Piperazine - PIP Market Analysis by Type

Piperazine Anhydrous

Piperazine anhydrous is also known as hexahydropyrazine. Piperazine anhydrous is an organic compound that finds application in several industrial applications. It is a cyclic diamine with a chemical formula of C4H10N2. Piperazine anhydrous is also known as piperazine flakes, which is used as a raw material for several commercially available drugs. Piperazine anhydrous is suitable raw material for quinolone drugs, such as ciprofloxacin, and norfloxacin. It is used in the manufacture of other drugs such as anti-helminthics, sedatives, antihistaminic, anti-filarial, tranquilizers, and analgesics. Piperazine anhydrous is mainly used in pharmaceutical applications

68 Piperazine

Piperazine 68% is a cyclic amine, used for several applications such as pharmaceutical, agrochemicals, personal care products, and agrochemicals. Piperazine 68% contains 68% of the active content diluted with water. Piperazine 68% application includes pharmaceutical, polyamide, gas sweetening, and PU catalysts.

The rising population results in a growing prevalence of diseases, which in turn boosts the demand for pharmaceutical drugs. The rising demand for pharmaceutical drugs to treat diseases fuels the demand for piperazine 68% solution.

Furthermore, the piperazine 68% is also suitable for use in the agrochemical sector. Piperazine is 68% used in the production of insecticides, herbicides, and fungicides, which meet the demand for high-quality crop yield.
However, the increase in consumer preference towards the purchase of personal care products boosts the demand for piperazine 68% solution. This solution is used in the manufacturing of several personal care industries.

Others

Piperazine is an organic chemical compound with 99% purity. Merck KGaA offers piperazine 99% as an intermediate for the production of pharmaceutical, drugs, corrosion inhibitors, rubber accelerators, and surfactants. The Thermofishcer Scientific offers piperazine anhydrous 99% acts as an intermediate for the production of plastic, polyamide resin, urethane, and brake fluid products.

Piperazine with a purity of 95% is used for several industrial applications. The Parkway Scientific LLC. Offers piperazine 95% for use as a chemical intermediate in chemicals, pharmaceutical, and agrochemical applications.

The above Graph is for representation purposes only. This chart does not depict actual Market share.

Piperazine PIP Application Segment Analysis

Adhesives and Sealants

The piperazine is used in adhesives and sealants, as it improves bonding and sealing properties. Piperazine is used in the production of polyamides for hot-melt, pressure-sensitive, and heat-seal adhesives for leather, paper, plastic, and metal. Piperazine is used as binders in inks, coating, adhesives, and sealants. 

BASF SE designs piperazine 68% solution, which is used in adhesives and sealants. The demand for specialty adhesives is increasing in the automotive sector, as manufacturers switch to plastics, composites, and non-ferrous materials for construction. 

The adoption of specialty adhesives in the automotive sector helps in the reduction of vehicles. According to the data published by S&P Global, in 2022, the consumption of specialty adhesives 
accounts for 9% of the global market. The rise in consumption of adhesives boosts the demand for piperazine.

Paint & Coatings

Piperazine is used in several chemical industries, as a catalyst for polymerization of monomers. The piperazine is used for the production of polymer in several applications as coatings, and adhesives. Major manufacturers such as Nouryon, BASF, and other offers piperazine which finds its application in the making of epoxy curing agent, and as a catalyst in polymerization, which increases its usage in coatings and paints. Piperazine anhydrous, piperazine 68% finds application in coating and paints.

Chemical Intermediates 

A chemical intermediate is a substance used for the transformation of one product to another and used in chemical processing applications. The BASF SE is uses N-methyl piperazine as a specialty intermediate in the production of active pharmaceutical ingredients. Furthermore, N-methyl piperazine is used as an intermediate in the processing of textile fibres. BASF SE offers its industrial-grade piperazine chip as an intermediate in the production of epoxy systems.

Pesticides

Agrochemicals are used in agriculture to control pests, and pathogens, and supply nutrients to soil. Agrochemicals include pesticides insecticides, herbicides, and fungicides for the protection of crops and improving agricultural yield. Piperazine is used in the research and development of agrochemicals. Alliance Chemicals offers piperazine 68% aqueous solution is used in the manufacturing of pesticides. The advantage of piperazine is its additive products, and it is thermally stable and cost-effective, which makes its usage in the production of agrochemicals.

Others

The piperazine has an application for the dyeing process in textile fibers. Delamine offers piperazine flakes, also known as piperazine anhydrous used in textile and sports applications, as a chelating agent, polyamide resins, and urethane chemicals.

Piperazine is also used as a pharmaceutical drug in animal livestock and poultry. Hindustan Therapeutics Ltd. offers piperazine suspension, which is suitable for oral administration during the treatment of roundworm infection in poultry and livestock.

• Adhesives and Sealants
• Paint & Coatings
• Chemical Intermediates
• Pesticides
• Others

Piperazine PIP End-use Industry Segment Analysis

Food & Beverages

Piperazine is used as a food additive in the food and beverage sector. The piperazine also finds application in animals Marco Rubber and Plastics offers piperazine which is an organic compound used in food flavoring agents. 

Pharmaceutical

Pharmaceutical-grade piperazine is used in the synthesis of pharmaceutical drugs. This chemical compound is used in pharmaceutical research and medical research. Pharmaceutical-grade piperazine is used as an anthelmintic agent for the treatment of parasitic infections in humans, and animals. The piperazine is used in medical research for the discovery and development of potent drugs. Merck KGaA offers piperazine anhydrous for synthesis in the pharmaceutical industry. BASF SE offers piperazine chips, which are used as building blocks in the synthesis of APO such as floxacin, quinolones, phenothiazines, and antihelmintics. Furthermore, piperazine chips are used in the development of viagra.

Textile

Piperazine is used as an additive in the textile industry. The presence of several manufacturers offers different types of piperazine suitable for the textile sector. The Atman Chemicals Ltd. utilizes N-methyl piperazine as an additive in the processing of textile fibers. HT Fine Chemical Co., Ltd. uses piperazine as a finishing agent in textiles. The piperazine is modified to piperazine silicone oil and emulsion, which is used as a fabric finishing agent for the making of cotton, linen, wool, and blended fabric. The use of piperazine-modified silicone oil achieves inhibition yellowing and offers a soft texture to the fabric.

Personal Care & Cosmetics

Piperazine is a white, crystalline solid. which is highly soluble in water. It has a characteristic odor and is alkaline in taste. The piperazine shows stability under normal conditions of use and storage. Piperazine also known as Bis diethylamino hydroxy benzoyl peroxide is used as an ingredient in cosmetic products. Piperazine is used as a UV filter for the protection of skin or hair from harmful UV radiation. The UV filter in sunscreen and other cosmetics with UV protection, minimizes the undesired effects of UV radiation on the skin. The increase in demand for sunscreen boosts demand for piperazine as an ingredient. However, the use of piperazine has shown side effects on human skin on its exposure. The Scientific Advisory Group on Chemicals Safety of Non-Food and Non-Medicinal Consumer Products (SAG-CS) is a UK regulatory body, which evaluates the safety of substances used in cosmetics products. 

Agriculture

Piperazine is used in the discovery of agrochemicals. The piperazine is used in research laboratories for the development of new pesticides. Farm Supplies Brisbane uses piperazine 100ml as an intermediate in the manufacture of pesticides, and insecticides. N-methyl piperazine manufactured by Atman Chemicals Ltd. is used in pesticides, dyes, and plastic products.

Chemical

Piperazine is used as a chemical intermediate for the synthesis of chemicals. Diamines and Chemicals Ltd. offers piperazine anhydrous is used for specialty chemicals such as corrosion inhibitors, photographic chemicals, wetting agents, polyamides, rubber auxiliaries, and as a hardener for epoxy resins. Thermofishcer Scientific offers piperazine anhydrous, piperazine 68%, which acts as an intermediate for dyes, rubber accelerates, and surfactants.

Oil & gas

Piperazine is used in the oil and gas sector. The piperazine is used for the removal of CO2 for carbon capture and storage. This compound offers protection from thermal and oxidative degradation at typical coal flue gas conditions. 

Furthermore, the addition of piperazine to amine gas is used for the treatment of solvents, and it shows CO2 absorption, and heat absorption, and increases solvent capacity’s piperazine is also used to thermally regenerate with the help of multi-stage flash distillation and another method which has operating temperature of 150 degree C and recycled back in the absorption process by offering high energy during the amine gas treating processes’ SE offers piperazine is used as an additive in CO2 and HS2 gas treatment areas.

Industrial

Piperazine is an organic chemical compound that is used to produce plastic, resins, and other industrial materials. Piperazine in its anhydrous form and piperazine 86% aqueous solution is used for the manufacturing of plastics. Alliance Chemicals offers piperazine 68% aqueous solution for the manufacturing of plastics. Thermo Fischer Scientific offers piperazine anhydrous, and 99% offers piperazine as an intermediate for manufacturing plastics, urethane, brake fluid, resin, and others. Hefei TNJ Chemical Industry Co., Ltd. offers piperazine anhydrous as an intermediate for chemicals, such as dyes, and pesticides.

• Food & Beverages
• Pharmaceutical
• Textile
• Personal Care & Cosmetics
• Agriculture
• Chemical
• oil & gas
• Industrial
• Others

Author's Detail

Manoj Phagare

Senior Research Analyst at Cognitive Market Research

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